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KMID : 0370220150590060266
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Yakhak Hoeji
2015 Volume.59 No. 6 p.266 ~ p.269
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Anticoccidial Effect of 3-(4-Methoxybenzylaminomethylene)-1,3-dihydroindole-2-one(5-108)
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여선주:Yeo Seon-Ju
김학성:Kim Hak-Sung/김석:Kim Suk/이기인:Lee Kee-In/박현:Park Hyun
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Abstract
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Coccidiosis is induced by Toxoplasma gondii and Eimeria tenella and novel anticoccidial drugs have been requested. In this study, the anticoccidial effect of 3-(4-methoxybenzylaminomethylene)-1,3-dihydroindole-2-one (5-108) on T. gondii and E. tenella was evaluated. Novel synthetic derivative 5-108 showed 1.44 fold higher relative selectivity compared to pyrimethamine against T. gondii in vitro assay. In chicken study, compound 5-108 significantly decreased the number
of oocytes of E. tenella in feces, obtained from E. tenella-infected chickens, by 33±2.64% and 23±3.60% (P<0.001) at
7th day and 9th day p.i.. Conclusively, compound 5-108 was effective against T. gondii and E. tenella.
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KEYWORD
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Toxoplasma gondii, Eimeria tenella, anticoccidial effect, selectivity, 5-108
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